Publikationen

Weller JF, Lengerke C, Finke J, Schetelig J, Platzbecker U, Einsele H, Schroeder T, Faul C, Stelljes M, Dreger P, Blau IW, Wulf G, Tischer J, Scheid C, Elmaagacli A, Neidlinger H, Flossdorf S, Bornhäuser M, Bethge W, Fleischhauer K, Kröger N, De Wreede LC, Christopeit M. Allogeneic hematopoietic stem cell transplantation in patients aged 60-79 years in Germany (1998-2018): a registry study. Haematologica 2023 Aug 31. doi: 10.3324/haematol.2023.283175. Online ahead of print. PMID: 37646665

Arrieta-Bolaños E, Hernández-Zaragoza DI, Barquera R. An HLA map of the world: A comparison of HLA frequencies in 200 worldwide populations reveals diverse patterns for class I and class II. Front Genet 2023 Mar 23;14:866407. doi: 10.3389/fgene.2023.866407. eCollection 2023. PMID: 37035735

Leserer S, Graf T, Franke M, Bogdanov R, Arrieta-Bolaños E, Buttkereit U, Leimkühler N, Fleischhauer K, Reinhardt HC, Beelen DW, Turki AT. Time series clustering of T cell subsets dissects heterogeneity in immune reconstitution and clinical outcomes among MUD-HCT patients receiving ATG or PTCy.  Front Immunol 2023 Mar 20;14:1082727. doi: 10.3389/fimmu.2023.1082727. eCollection 2023. PMID: 37020562

Fleischhauer K. Improved Accessibility of Optimally Matched Stem Cell Donors. Transplant Cell Ther. 2023 Apr;29(4):213-214. doi: 10.1016/j.jtct.2023.03.004. PMID: 36966010

Fleischhauer K, Tran TH, Meisel R, Mytilienos J, Dreger P, Kröger N. Donor Selection for Allogeneic Hematopoietic Cell Transplantation. Dtsch Arztebl Int 2023, Apr 14;120(15):261-268. doi: 10.3238/arztebl.m2023.0031. PMID: 36949660

Crivello P, Arrieta-Bolaños E, He M, Wang T, Fingerson S, Gadalla SM, Paczesny S, Marsh SGE, Lee SJ, Spellman SR, Bolon YT, Fleischhauer K. Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation. J Clin Oncol 2023 May 1;41(13):2416-2427. doi: 10.1200/JCO.22.01229. Epub 2023 Jan 20. PMID: 36669145

Frietsch JJ, Flossdorf S, Beck JF, Kröger N, Fleischhauer K, Dreger P, Schetelig J, Bornhäuser M, Hochhaus A, Hilgendorf I. Outcomes after allogeneic haematopoietic stem cell transplantation in young adults in Germany. Br J Haematol 2022 Apr;201(2):308-318. doi: 10.1111/bjh.18610. Epub 2022 Dec 27. PMID: 36573337

Kröger N, Frank S, Neidlinger H, Fleischhauer K, Dreger P. The Number of Stem Cell Transplantations During the COVID-19 Pandemic. Dtsch Arztebl Int 2022 Sep 5;119(35- 36):601-602. doi: 10.3238/arztebl.m2022.0239. PMID: 36474337

Merli P, Crivello P, Strocchio L, Pinto RM, Algeri M, Del Bufalo F, Pagliara D, Becilli M, Carta R, Gaspari S, Galaverna F, Quagliarella F, Boz G, Catanoso ML, Boccieri E, Troiano M, Fleischhauer K, Andreani M, Locatelli F. Human leukocyte antigen evolutionary divergence influences outcomes of paediatric patients and young adults affected by malignant disorders given allogeneic haematopoietic stem cell transplantation from unrelated donors. Br J Haematol 2023 Mar;200(5):622-632. doi: 10.1111/bjh.18561. doi: 10.1111/bjh.18561. Epub 2022 Nov 16. PMID: 36385618

Ruggeri A, De Wreede LC, Müller CR, Crivello P, Bonneville EF, Petersdorf EW, Socié G, Dubois V, Niittyvuopio R, Peräsaari J, Yakoub-Agha I, Cornelissen JJ, Wieten L, Gedde-Dahl T, Forcade E, Crawley CR, Marsh SGE, Gandemer V, Tholouli E, Bulabois CE, Huynh A, Choi G, Deconinck E, Itäla-Remes M, Lenhoff S, Bengtsson M, Johansson JE, Van Gorkom G, Hoogenboom JD, Vago L, Rocha V, Bonini C, Chabannon C, Fleischhauer K. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation.  Haematologica 2023 Feb 1;108(2):645-652. doi: 10.3324/haematol.2021.280055. PMID: 35546480

Kröger N, Frank S, Neidlinger H, Fleischhauer K, Dreger P. The Number of Stem Cell Transplantations During the COVID-19 Pandemic. Dtsch Arztebl Int. 2022 Sep 5;119(35-36):601-602. doi: 10.3238/arztebl.m2022.0239. PMID: 36474337; PMCID: PMC9749841.

Arrieta-Bolaños E, Crivello P, He M, Wang T, Gadalla SM, Paczesny S, Marsh SGE, Lee SJ, Spellman SR, Bolon YT, Fleischhauer K. A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation. Blood. 2022 Aug 11;140(6):659-663. doi: 10.1182/blood.2022015708. PMID: 35609150; PMCID: PMC9373015.

Fleischhauer K. Haplo-PtCy: adjusting the HLA barrier. Blood. 2022 Mar 10;139(10):1431-1433. doi: 10.1182/blood.2021014532. PMID: 35267004.

Turki AT, Tsachakis-Mück N, Leserer S, Crivello P, Liebregts T, Betke L, Alashkar F, Leimkühler NB, Trilling M, Fleischhauer K, Beelen DW. Impact of CMV reactivation on relapse of acute myeloid leukemia after HCT is dependent on disease stage and ATG. Blood Adv. 2022 Jan 11;6(1):28-36. doi: 10.1182/bloodadvances.2021005509. PMID: 34619756; PMCID: PMC8753205.

Leserer S, Arrieta-Bolaños E, Buttkereit U, Beelen DW, Turki AT. Combined Analysis of Early CD4+ T Cell Counts and CMV Serostatus May Improve CMV Risk Assessment after Allogeneic Hematopoietic Cell Transplantation. Cells. 2021 Nov 26;10(12):3318. doi: 10.3390/cells10123318. PMID: 34943824; PMCID: PMC8699729.

Harbers FN, Thier B, Stupia S, Zhu S, Schwamborn M, Peller V, Chauvistré H, Crivello P, Fleischhauer K, Roesch A, Sucker A, Schadendorf D, Chen Y, Paschen A, Zhao F. Melanoma Differentiation Trajectories Determine Sensitivity toward Pre-Existing CD8+ Tumor-Infiltrating Lymphocytes. J Invest Dermatol. 2021 Oct;141(10):2480-2489. doi: 10.1016/j.jid.2021.03.013. Epub 2021 Mar 30. PMID: 33798535..

Leserer S, Bayraktar E, Trilling M, Bogdanov R, Arrieta-Bolaños E, Tsachakis-Mück N, Crivello P, Koldehoff M, Maaßen F, Ross RS, Fleischhauer K, Beelen DW, Turki AT. Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution. Am J Hematol. 2021 Apr 1;96(4):436-445. doi: 10.1002/ajh.26094. Epub 2021 Feb 12. PMID: 33439488.

Meurer T, Crivello P, Metzing M, Kester M, Megger DA, Chen W, van Veelen PA, van Balen P, Westendorf AM, Homa G, Layer SE, Turki AT, Griffioen M, Horn PA, Sitek B, Beelen DW, Falkenburg JHF, Arrieta-Bolaños E, Fleischhauer K. Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM. Blood. 2021 Feb 18;137(7):923-928. doi: 10.1182/blood.2020008464. PMID: 33025005.

Camacho-Bydume C, Wang T, Sees JA, Fernandez-Viña M, Abid MB, Askar M, Beitinjaneh A, Brown V, Castillo P, Chhabra S, Gadalla SM, Hsu JM, Kamoun M, Lazaryan A, Nishihori T, Page K, Schetelig J, Fleischhauer K, Marsh SGE, Paczesny S, Spellman SR, Lee SJ, Hsu KC. Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes. Transplant Cell Ther. 2021 Feb;27(2):142.e1-142.e11. doi: 10.1016/j.bbmt.2020.10.010. Epub 2020 Oct 11. PMID: 33053450; PMCID: PMC8015676.

Lorentino F, Labopin M, Ciceri F, Vago L, Fleischhauer K, Afanasyev B, Kröger N, Cornelissen JJ, Lovira M, Meijer E, Vitek A, Elmaagacli A, Blaise D, Ruggeri A, Chabannon C, Nagler A, Mohty M; Acute Leukemia Working Party (ALWP) and Cellular Therapy and Immunobiology Working Party (CTIWP) of the European Society for Blood and Marrow Transplantation (EBMT). Post-transplantation cyclophosphamide GvHD prophylaxis after hematopoietic stem cell transplantation from 9/10 or 10/10 HLA-matched unrelated donors for acute leukemia. Leukemia 2021 Feb;35(2):585-594. Epub 2020 May 14. doi: 10.1038/s41375-020-0863-4. PMID: 32409688.

Dhakal B, Wang T, Kuxhausen M, Zhu F, Taylor C, Spellman SR, Verneris MR, Hsu K, Fleischhauer K, Lee SJ, Bolon YT, Carlson KS, Nazha A, Saber W. Prognostic impact of serum CXC chemokine ligands 4 and 7 on myelodysplastic syndromes post allogeneic hematopoietic cell transplant. Leuk Lymphoma. 2021 Jan;62(1):229-233. doi: 10.1080/10428194.2020.1817446. Epub 2020 Sep 13. PMID: 32924688; PMCID: PMC7939047.

Barquera R, Hernández-Zaragoza DI, Bravo-Acevedo A, Arrieta-Bolaños E, Clayton S, Acuña-Alonzo V, Martínez-Álvarez JC et al. The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure. Hum Immunol. 2020 Sep;81(9):461-474. doi: 10.1016/j.humimm.2020.06.008. Epub 2020 Jul 8. PMID: 32651014.

Petersdorf EW, Bengtsson M, De Santis D, Dubois V, Fleischhauer K, Gooley T, Horowitz M, Madrigal JA, Malkki M, McKallor C, Morishima Y, Oudshoorn M, Spellman SR, Villard J, Stevenson P, Carrington M; the; International Histocompatibility Working Group in Hematopoietic-Cell Transplantation. Role of HLA-DP Expression in Graft-Versus-Host Disease After Unrelated Donor Transplantation. J Clin Oncol. 2020 Aug 20;38(24):2712-2718. doi: 10.1200/JCO.20.00265. Epub 2020 Jun 1. PMID: 32479188; PMCID: PMC7430213.

van Balen P, Kester MGD, de Klerk W, Crivello P, Arrieta-Bolaños E, de Ru AH, Jedema I, Mohammed Y, Heemskerk MHM, Fleischhauer K, van Veelen PA, Falkenburg JHF. Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies. J Immunol 2020 Jun 15;204(12):3273-3282. Epub 2020 Apr 29.  doi:  10.4049/jimmunol.2000192. PMID: 32350084.

Schetelig J, Baldauf H, Heidenreich F, Massalski C, Frank S, Sauter J, Stelljes M, Ayuk F, Bethge WA, Bug G, Klein S, Wendler S, Lange V, de Wreede LC, Fuerst D, Kobbe G, Ottinger HD, Beelen DW, Mytilineos J, Fleischhauer K, Schmidt AH, Bornhauser M. External Validation of Models for KIR2DS1/KIR3DL1-informed Selection of Hematopoietic Cell Donors fails. Blood 2020 Apr 16;135(16):1386-1395. Epub 2020 Jan 13. pii: blood.2019002887. doi: 10.1182/blood.2019002887. PMID: 31932846.

Lorentino F, Sacchi N, Oldani E, Miotti V, Picardi A, Gallina AM, Crivello P, Bernasconi P, Saccardi R, Farina L, Benedetti F, Cerno M, Grassi A, Bruno B, Patriarca F, Ciceri F, Fleischhauer K, Vago L, Bonifazi F. Comparative evaluation of biological human leukocyte antigen DPB1 mismatch models for survival and graft-versus-host disease prediction after unrelated donor hematopoietic cell transplantation. Haematologica. 2020 Apr;105(4):e186-e189. doi: 10.3324/haematol.2019.225177. Epub 2019 Aug 30. PMID: 31471374; PMCID: PMC7109721.

Arrieta-Bolaños E, Oliveira DC, Barquera R. Differential admixture, human leukocyte antigen diversity, and hematopoietic cell transplantation in Latin America: challenges and opportunities. Bone Marrow Transplant. 2020 Mar;55(3):496-504. doi: 10.1038/s41409-019-0737-4. Epub 2019 Nov 6. PMID: 31695172.

Turki AT, Klisanin V, Bayraktar E, Kordelas L, Trenschel R, Ottinger H, Steckel NK, Tsachakis-Mück N, Leserer S, Ditschkowski M, Liebregts T, Koldehoff M, Fleischhauer K, Beelen DW. Optimizing anti-T-lymphocyte globuline dosing to improve long-term outcome after unrelated hematopoietic cell transplantation for hematologic malignancies. Am J Transplant 2020 Mar;20(3):677-688. Epub 2019 Nov 16. doi: 10.1111/ajt.15642. PMID: 31597002.

Jana N, Milena V, Eva R, Sara N, Šárka P, Cyril Š, Pietro C, Jana B, Monika B, Evangelista DJ. The formation of a somatic mutation in the HLA-B gene throughout the development of the disease from severe aplastic anaemia to acute myeloid leukaemia. HLA. 2019 Dec;94 Suppl 2:30-33. doi: 10.1111/tan.13762. PMID: 31733047.

Fleischhauer K. Selection of matched unrelated donors moving forward: from HLA allele counting to functional matching. Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):532-538. doi: 10.1182/hematology.2019000057. PMID: 31808865; PMCID: PMC6913495.

Tsamadou C, Fürst D, Wang T, He N, Lee SJ, Spellman SR, Fleischhauer K, Hsu KC, Paczesny S, Verneris MR, Schrezenmeier H, Mytilineos J. Donor HLA-E Status Associates with Disease-Free Survival and Transplant-Related Mortality after Non In Vivo T Cell-Depleted HSCT for Acute Leukemia. Biol Blood Marrow Transplant. 2019 Dec;25(12):2357-2365. doi: 10.1016/j.bbmt.2019.08.007. Epub 2019 Aug 16. PMID: 31425756; PMCID: PMC7050288.

Pingel J, Wang T, Hagenlocher Y, Hernández-Frederick CJ, Nagler A, Haagenson MD, Fleischhauer K, Hsu KC, Verneris MR, Lee SJ, Mohty M, Polge E, Spellman SR, Schmidt AH, van Rood JJ. The effect of NIMA matching in adult unrelated mismatched hematopoietic stem cell transplantation – a joint study of the Acute Leukemia Working Party of the EBMT and the CIBMTR. Bone Marrow Transplant 2019 Jun;54(6):849-857. Epub 2018 Oct 2. doi: 10.1038/s41409-018-0345-8. PMID: 30279575.

Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini MM, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen DW, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes CJM, Griffioen M, Carrabba MG, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic D, Tonon G, Rambaldi A, Cittaro D, Bonini C, Fleischhauer K, Ciceri F, Vago L. Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation. Nat Med. 2019 Apr;25(4):603-611. doi: 10.1038/s41591-019-0400-z. Epub 2019 Mar 25. PMID: 30911134.

Askar M, Sayer D, Wang T, Haagenson M, Spellman SR, Lee SJ, Madbouly A, Fleischhauer K, Hsu KC, Verneris MR, Thomas D, Zhang A, Sobecks RM, Majhail NS; Center for International Blood and Marrow Transplant Research Immunology Working Committee. Analysis of Single Nucleotide Polymorphisms in the Gamma Block of the Major Histocompatibility Complex in Association with Clinical Outcomes of Hematopoietic Cell Transplantation: A Center for International Blood and Marrow Transplant Research Study. Biol Blood Marrow Transplant. 2019 Apr;25(4):664-672. doi: 10.1016/j.bbmt.2018.12.008. Epub 2018 Dec 8. PMID: 30537553; PMCID: PMC6453713..

Crivello P, Ahci M, Maaßen F, Wossidlo N, Arrieta-Bolaños E, Heinold A, Lange V, Falkenburg JHF, Horn PA, Fleischhauer K, Heinrichs S. Multiple Knockout of Classical HLA Class II β-Chains by CRISPR/Cas9 Genome Editing Driven by a Single Guide RNA. J Immunol. 2019 Mar 15;202(6):1895-1903. doi: 10.4049/jimmunol.1800257. Epub 2019 Jan 30. PMID: 30700588.

Arrieta-Bolaños E, Fleischhauer K. Learning the next-generation sequencing alphabet of immune reconstitution: factors determining CD8+ T-cell receptor α-chain repertoire dynamics after hematopoietic stem cell transplantation. Haematologica. 2019 Mar;104(3):422-425. doi: 10.3324/haematol.2018.209130. PMID: 30819834; PMCID: PMC6395333.

Woolfrey A, Wang T, Lee SJ, Haagenson MD, Chen G, Fleischhauer K, Horan J, Hsu K, Verneris M, Spellman SR, Fernandez-Vina M. Donor-specific anti-HLA antibodies in unrelated hematopoietic cell transplantation for non-malignant disorders. Bone Marrow Transplant 2019 Mar;54(3):494-496. Epub 2018 Sep 19.  doi: 10.1038/s41409-018-0334-y. PMID: 30232414.

Fleischhauer K, Hsu KC, Shaw BE. Prevention of relapse after allogeneic hematopoietic cell transplantation by donor and cell source selection. Bone Marrow Transplant. 2018 Dec;53(12):1498-1507. doi: 10.1038/s41409-018-0218-1. Epub 2018 May 24. PMID: 29795435; PMCID: PMC7286200.

Ayuk F, Beelen DW, Bornhäuser M, Stelljes M, Zabelina T, Finke J, Kobbe G, Wolff D, Wagner EM, Christopeit M, Schmid C, Ottinger H, Groth C, Faul C, Bertz H, Rachlis E, Wolschke C, Schetelig J, Horn PA, Mytilineos J, Guellstorf M, Kelsch R, Fleischhauer K, Kröger N, Bethge W. Relative Impact of HLA Matching and Non-HLA Donor Characteristics on Outcomes of Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome. Biol Blood Marrow Transplant 2018 Dec;24(12):2558-2567. Epub 2018 Jul 24. doi: 10.1016/j.bbmt.2018.06.026. PMID: 29966760.

Meurer T, Arrieta-Bolaños E, Metzing M, Langer MM, van Balen P, Falkenburg JHF, Beelen DW, Horn PA, Fleischhauer K, Crivello P. Dissecting Genetic Control of HLA-DPB1 Expression and Its Relation to Structural Mismatch Models in Hematopoietic Stem Cell Transplantation. Front Immunol. 2018 Oct 5;9:2236. doi: 10.3389/fimmu.2018.02236. PMID: 30344521; PMCID: PMC6183238..

Eberhard HP, Schmidt AH, Mytilineos J, Fleischhauer K, Müller CR. Common and well-documented HLA alleles of German stem cell donors by haplotype frequency estimation. HLA. 2018 Oct;92(4):206-214. doi: 10.1111/tan.13378. PMID: 30117303; PMCID: PMC6175154..

Greco R, Ciceri F, Noviello M, Bondanza A, Vago L, Oliveira G, Peccatori J, Cieri N, Ruggeri A, Koehl U, Fleischhauer K, Rocha V, Dazzi F, van der Werf SM, Eikema DJ, Terwel SR, Kuball J, Toubert A, Chabannon C, Bonini C; EBMT Cellular Therapy and Immunobiology Working Party (CTIWP). Immune monitoring in allogeneic hematopoietic stem cell transplant